Please tell us more about how you use this in your app builder. I'd love to see this implemented for real-time native response per online edit. Got a link you can share?
We don't have real-time changes yet - to do so we'd probably use something like Simperium.
What we do now is reload an iframe showing the app.io embedded viewer. The iframe's URL supports specifying arbitary parameters that show up in NSUserDefaults. Upon launch, our app checks these parameters and uses it to connect to our backend and retrieve its latest configuration.