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you want to be a little careful.

genetic bottleneck does not imply population loss.

it is about unavailability of large gene pool.

this can be population loss, but can also, be a loss of compatability between individuals, due to genomic modification, such as but not limited to chromosomal fusion.

https://www.johnhawks.net/p/when-did-human-chromosome-2-fuse

https://en.wikipedia.org/wiki/Robertsonian_translocation



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