Love the idea of Plume; signed up to the mailing list. Btw the website layout breaks on very wide browsers (images in the .features-section overlap text). Maybe consider some max-width for the page.
And I also have to say that my days with Qt are quite some time ago. I never really got into QML, so if you say that QML is a great choice I'd put more weight on your word than on mine.
Qt Quick (The Qt Company's library that is exposed in QML) is very advanced today. I'm able to do things that would be considered very difficult with Qt Widgets. For example: true drag and drop between items in a virtualized list: https://twitter.com/plumenotes/status/1772599295243440137
Also, they started to work well on native widgets (at least on macOS), for example they support native dialogs, context menus, etc. Very helpful.
I'll probably write a blog post about the development and architecture (some said they'd be interested).